Xiaolong Jiang

This study identifies a common inhibitory cortical circuit disruption in two genetically distinct absence epilepsy mouse models that leads to seizure onset.

The paper identifies molecular logic underlying cellular specializations in the cochlear nuclear complex using single-nucleus RNA sequencing and Patch-seq.

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

The paper identifies hybrid cells in human glioma with both neuronal and glial electrophysiological and transcriptomic features using Patch-sequencing and a new computational tool.

The paper investigates the local circuit organization of noradrenergic neurons in the locus coeruleus of adult mice, revealing diverse morpho-electric types and chain-like electrical coupling patterns.

The paper identifies distinct feedback circuit motifs in cortico-cortical pathways, showing different functional dynamics in motor-sensory and visual feedback circuits.

The paper introduces a CRISPR toolkit for generating intersectional genetic mice to study cellular circuits, demonstrating its use in neuronal and ovarian populations.

This study shows that removing KCNQ2 from parvalbumin-expressing interneurons enhances the anti-seizure efficacy of retigabine.

The paper combines morpho-electric and transcriptomic data from mouse motor cortex neurons to show that transcriptomic types within families form continuous morpho-electric landscapes rather than discrete entities.

The paper characterizes cell types and circuit organization within neocortical radial clones using single-cell RNA-sequencing and electrophysiological recordings, finding that clones contain diverse cell types and exhibit specific connectivity patterns.

The paper identifies distinct cell types and circuit organization in layer 4 of primary sensory areas in adult mouse neocortex, challenging the canonical microcircuit model.