Author

Tetsushi Furukawa

Tokyo Medical and Dental UniversityORCID 0000-0001-8070-6027Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Akashi Taguchi· 2 shared Hiroyuki AburataniiD· 2 shared Masaomi NangakuiD· 2 shared Nao Nagai· 2 shared Yasuharu KankiiD· 2 shared Yoshiki HigashijimaiD· 2 shared Youichiro WadaiD· 2 shared Akinori KimuraiD· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Akashi Taguchi

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3 papers

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedNov 30, 2020

Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of Hox gene cluster

Yoshiki Higashijima, Nao Nagai, Masamichi Yamamoto…·Yasuharu Kanki

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

13 citations

mouseexperimental assay

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Molecular BiologyThe EMBO JournalPeer-reviewedMar 3, 2020

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura…·Yasuharu Kanki

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.

53 citations

humanDNA methylation

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Developmental BiologyDisease Models & MechanismsPeer-reviewedJan 1, 2019

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients.

Yuta Higashikuse, Nishant Mittal, Takuro Arimura…·Shinji Makino

The paper identifies mutations in the titin Ig domain associated with hypertrophic cardiomyopathy in both a fish model and human patients, showing increased titin-MURF1 binding and degradation.

19 citations

zebrafishhuman

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