Yoshiki Higashijima

This study shows cohesin and CTCF regulate gene expression through both architectural and direct transcriptional mechanisms, with CTCF also acting as a transcriptional activator independent of cohesin.

The paper identifies H2B acetylation as a marker for active enhancers and shows it predicts enhancer target genes better than existing methods.

The paper investigates how native enhancers interact with promoters to shape cell-type-specific gene expression and shows that enhancers can regulate both developmental and housekeeping genes.

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.