Author

Yasuharu Kanki

Isotope Science Center, The University of TokyoORCID 0000-0002-3795-3919Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Hiroyuki AburataniiD· 3 shared Youichiro WadaiD· 3 shared Akashi Taguchi· 2 shared Hiroshi KimurâiD· 2 shared Masaomi NangakuiD· 2 shared Nao Nagai· 2 shared Ryo Nakaki· 2 shared Shuichi Tsutsumi· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Hiroyuki AburataniORCID

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3 papers

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedNov 30, 2020

Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of Hox gene cluster

Yoshiki Higashijima, Nao Nagai, Masamichi Yamamoto…·Yasuharu Kanki

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

13 citations

mouseexperimental assay

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Molecular BiologyThe EMBO JournalPeer-reviewedMar 3, 2020

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

Yoshiki Higashijima, Yusuke Matsui, Teppei Shimamura…·Yasuharu Kanki

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.

53 citations

humanDNA methylation

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GenomicsEpigenetics & ChromatinPeer-reviewedDec 1, 2019

Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

Ryuichiro Nakato, Youichiro Wada, Ryo Nakaki…·Katsuhiko Shirahige

The paper characterizes the transcriptomic and epigenomic landscape of nine human endothelial cell types, identifying EC-specific enhancers and marker genes, and highlights the role of HOX genes in vascular development and disease.

38 citations

humanbulk RNA-seq

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