Akashi Taguchi

Hox-Meis-relayed gene regulatory transition underlies cardiopharyngeal neural crest diversification

The paper maps lineage trajectories and gene regulatory networks of cardiopharyngeal neural crest cells in mice, identifying a Hox-Meis-regulated transition associated with cardiac cushion development.

Novel therapy for gastric cancer peritoneal dissemination using genetically modified dental pulp cells and astatine-211

This paper develops a novel therapy for gastric cancer peritoneal dissemination using genetically modified dental pulp cells loaded with astatine-211, showing tumor regression and extended survival in mice.

Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis

The paper uses multimodal analysis to reveal cardiac neural crest lineage diversity and gene regulatory networks involved in their differentiation.

Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of Hox gene cluster

This study shows that Kdm7a regulates posterior Hox gene expression in mouse embryos by demethylating H3K9me2, leading to anterior-posterior developmental defects.

Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells

The paper shows that KDM7A and UTX demethylate repressive histone marks to enable NF-κB-dependent inflammatory gene activation in endothelial cells.