Noa Novershtern

Reconstituting Mouse Embryogenesis Ex Utero from Gastrulation to Fetal Development Reveals Maternally Independent Metabolic Programs

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

Human primed and naive PSCs are both competent indifferentiating into bona fide trophoblast stem cells

The paper shows that primed human pluripotent stem cells can be converted into trophoblast stem cells by inhibiting the TGFβ pathway, producing TSCs indistinguishable from those derived from placenta or naive PSCs.

Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naive Pluripotency

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

Context-dependent functional compensation between Ythdf m6A readers

The paper investigates functional compensation among Ythdf m6A readers in mouse gametogenesis and embryonic stem cells, revealing dosage-dependent redundancy and distinct roles.

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

This paper reviews recent advances in understanding the molecular mechanisms and signaling pathways that regulate pluripotent stem cell states in vitro and their reprogramming in somatic cells across species.

Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-differentiation with iPSC Reprogramming Factors

This study shows that most trans-differentiated cells derived from mouse fibroblasts using OSKM factors acquire pluripotency transiently before differentiation.