Thorsten R. Mempel

The paper identifies suppressive atypical memory B cells in AML that are amplified by CAR T cell interactions and shows that targeting both B cells and AML blasts can overcome this suppression.

The paper maps chemokine landscapes in solid tumors using spatial transcriptomics, identifying conserved and tumor-specific patterns and revealing perivascular CCR7 dendritic cells as key sources of lymphocyte-attracting chemokines.

This study identifies Dusp5 and Zfp219 as key regulators of age-related T cell dysfunction using CRISPR screens and shows their potential as therapeutic targets.

The paper identifies a cDC2-Treg feedback circuit in barrier tissues that limits Th2 cell expansion during allergic inflammation.

This study develops antibody-peptide epitope conjugates (APECs) to enhance anti-tumor activity in ICB-resistant HNSCC by leveraging viral peptide-loaded MHC I proteins and protease activity.

This study shows that delivering 4-1BBL via AAV enhances IL-12-induced anti-glioblastoma immunity in mouse models by boosting CD8 T cell activity and survival.