Lucía Álvarez-González

This paper creates a 3D epigenomic roadmap of human B-cell differentiation, revealing regulatory mechanisms in immunity and cancer.

The paper uses chromosome-level genome assembly and historical museum collections to study waterbuck population structure and chromosome evolution, finding genomic differentiation and recombination patterns linked to Robertsonian fusions.

The paper shows that clitellates experienced a burst of genomic rearrangements leading to loss of macrosynteny with marine annelids and new chromosomal interactions.

This study shows that DOT1L has opposing effects on gene expression in mouse spermatogenesis depending on chromatin environment, repressing some genes and activating others, particularly on the X chromosome.

The paper traces the origin and evolution of microchromosomes across birds, reptiles, and mammals, finding they are conserved and functionally coherent, with mammals being atypical in losing them.