Author

François Ichas

Centre National de la Recherche ScientifiqueORCID 0000-0001-8184-5248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:statistical model· 3 Organism:human· 2 Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Erwan BézardiD· 3 shared Florent LaferrièreiD· 3 shared Francesca De GiorgiiD· 3 shared Antoine LoquetiD· 2 shared Federica ZinghirinoiD· 2 shared Stéphane ClaveroliD· 2 shared Alons LendsiD· 1 shared Amanda J. LewisiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersNeuroscience

Erwan BézardORCID

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4 papers

Recent·Most cited

NeuroscienceNaturePeer-reviewedNov 5, 2025

Synthetic alpha-synuclein fibrils replicate in mice causing MSA-like pathology

Domenic Burger, Marianna Kashyrina, Lukas van den Heuvel…·François Ichas

This study shows synthetic alpha-synuclein fibrils can replicate in mice, causing MSA-like pathology and forming glial cytoplasmic inclusions.

24 citationstop 1%

mouseprotein structure

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Neurosciencenpj Parkinson s DiseasePeer-reviewedJan 13, 2022

Similar neuronal imprint and absence of cross-seeded partner fibrils in α-synuclein aggregates from MSA and Parkinson's disease brains

Florent Laferrière, Stéphane Claverol, Erwan Bézard…·François Ichas

The paper compares aggregated alpha-synuclein in Parkinson's disease and multiple system atrophy brains to determine their proteomic composition and potential cross-seeding mechanisms.

37 citationstop 4%

humanproteomics

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NeuroscienceScience AdvancesPeer-reviewedOct 2, 2020

Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons

Francesca De Giorgi, Florent Laferrière, Federica Zinghirino…·François Ichas

Stealth α-synuclein fibrils escape ThT detection, outcompete visible polymorphs, and spread neurodegeneratively in vivo.

80 citationstop 3%

protein structurestatistical model

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Molecular BiologyBiochimica et Biophysica Acta (BBA) - BioenergeticsPeer-reviewedAug 15, 2020

NRF-1 and HIF-1α modulate activity of human VDAC1 gene promoter during starvation and hypoxia in HeLa cells

Francesca Guarino, Federica Zinghirino, Lia Mela…·Angela Anna Messina

The paper investigates how NRF-1 and HIF-1α regulate VDAC1 promoter activity under starvation and hypoxia in HeLa cells, showing increased transcription under stress conditions.

34 citations

humanstatistical model

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