Author

Lia Mela

University of BernORCID 0000-0002-0882-0586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Adrian F. OchsenbeiniD· 1 shared Adrienne VancuraiD· 1 shared Ai Ming Tham· 1 shared Alden King-Yung LeungiD· 1 shared Alina NaveediD· 1 shared Álvaro AndradesiD· 1 shared Andrej BenjakiD· 1 shared Andrés LanzósiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenomics

Adrian F. OchsenbeinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A double-negative prostate cancer subtype is vulnerable to SWI/SNF-targeting degrader molecules

Phillip Thienger, Irene Paassen, Xiaosai Yao, Philip D. Rubin, Marika Lehner, Nicholas Lillis, Andrej Benjak, Sagar R Shah, Alden King-Yung Leung, Simone de Brot, Alina Naveed, Bence Dániel, Minyi Shi, Julien Tremblay, Joanna Triscott, , Mark A. Rubin

This study identifies a SWI/SNF-targeting therapy effective against a double-negative prostate cancer subtype, showing it reduces viability in both AR-dependent and WNT-dependent models.

Cancer Research · Jan 14, 2026Peer-reviewedCancer Biology

Tumour mutations in long noncoding RNAs enhance cell fitness

Roberta Esposito, Andrés Lanzós, Tina Uroda, Sunandini Ramnarayanan, Isabel Büchi, Taisia Polidori, Hugo Guillen-Ramirez, Ante Mihaljevic, Bernard Mefi Merlin, Lia Mela, Eugenio Zoni, Lusine Hovhannisyan, Finn McCluggage, Matúš Medo, Giulia Basile, , Rory Johnson

The paper identifies mutated long noncoding RNAs (lncRNAs) as contributors to tumour cell fitness through experimental validation of their oncogenic effects.

Nature Communications · Jun 8, 2023Peer-reviewedGenomics

NRF-1 and HIF-1α modulate activity of human VDAC1 gene promoter during starvation and hypoxia in HeLa cells

Francesca Guarino, Federica Zinghirino, Lia Mela, Xena Giada Pappalardo, François Ichas, Vito De Pinto, Angela Anna Messina

The paper investigates how NRF-1 and HIF-1α regulate VDAC1 promoter activity under starvation and hypoxia in HeLa cells, showing increased transcription under stress conditions.

Biochimica et Biophysica Acta (BBA) - Bioenergetics · Aug 15, 2020Peer-reviewedMolecular Biology