Domenic Burger

The paper examines ultrastructural differences between somatic and neuritic Lewy body inclusions in Parkinson's disease using correlative light and electron microscopy.

This study shows synthetic alpha-synuclein fibrils can replicate in mice, causing MSA-like pathology and forming glial cytoplasmic inclusions.

This paper provides a protocol for correlative light and electron microscopy (CLEM) optimized for analyzing human brain tissue, enabling detailed ultrastructural analysis and characterization of subcellular features.

Three fibril polymorphs, amplified from Parkinson's and multiple system atrophy brain homogenate by PMCA, adopt folds unlike any published alpha-synuclein arrangement; their disease relevance is untested.