Andrés Ozaita

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

This study shows that AM6545 treatment improves cognitive deficits in FX mice by modulating serotonergic receptors and gut microbiota.

CB1 receptor inhibition in fragile X syndrome mice impacts alternative splicing alterations in hippocampal synaptoneurosomal transcriptome

Sub-chronic peripheral CB1R inhibition enhances cognitive performance and induces hippocampal synaptic plasticity changes in naive mice

This study shows that sub-chronic peripheral CB1R inhibition improves memory and executive function in mice and alters hippocampal synaptic plasticity and gene expression.

Auricular transcutaneous vagus nerve stimulation acutely modulates brain connectivity in mice

This study shows that auricular transcutaneous vagus nerve stimulation (atVNS) improves memory persistence in mice when applied immediately after training but not 3 hours later, and induces reorganization of c-Fos-based brain connectivity.

Long-term decreased cannabinoid type-1 receptor activity restores specific neurological phenotypes in the Ts65Dn mouse model of Down syndrome

This study shows that long-term CB1R inhibition in Ts65Dn mice improves cognitive function without major side effects, suggesting potential therapeutic value for Down syndrome.

Cognitive and GABAergic protection by hAPPSw,Ind and hTauVLW coexpression: a model of Non-Demented with Alzheimer's disease Neuropathology

The paper identifies J20/VLW mice as a model for NDAN, showing preserved cognition and GABAergic pathways despite Aβ and P-Tau accumulation.

Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism

The paper shows that peripheral CB1R blockade enhances non-emotional memory through an adrenergic-dependent mechanism in mice.

A low repeated dose of Δ9-tetrahydrocannabinol affects memory performance through serotonergic signalling in mice

This study shows that repeated low-dose THC impairs memory in mice through serotonergic signaling via 5-HT2ARs, as evidenced by increased CB1R/5-HT2AR heterodimers and reduced LTP.