J. Javier Meana

This paper develops a dual-hit mouse model of schizophrenia combining maternal immune activation and postnatal THC exposure, finding reduced Reelin levels and altered brain structure in treated mice.

The paper introduces a low-input microfluidic method to profile lncRNA-chromatin interactions in disease-relevant tissues and cell types, revealing distinct roles of two lncRNAs in schizophrenia.

This study compares different CUMS protocols in mice, finding that increased stress intensity, frequency, and duration lead to more pronounced depressive and anxiety-like behaviors, adrenal hypertrophy, and reduced body weight gain.

This study identifies a shared miRNA-inflammatory axis linking Parkinson's disease, depressive disorder, and gut dysfunction through molecular convergence in human and mouse models.

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

This study identifies aberrant CPEB4 splicing and downstream mis-expression of SCZ-risk genes as a novel etiological mechanism in schizophrenia.

This study identifies a negative regulatory relationship between glucocorticoid receptor signaling and 5-HT2A receptor expression in a mouse model of neurodevelopmental disorder, linking it to synaptic and behavioral deficits.

The paper shows that peripheral CB1R blockade enhances non-emotional memory through an adrenergic-dependent mechanism in mice.

The paper identifies altered calcium-binding proteins in the cerebellum of schizophrenia patients, linking them to synaptic dysfunction and suicide behaviors.