Author

Jakub Sýs

Czech Academy of SciencesORCID 0000-0003-2589-1631Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aaron D. Showalter· 1 shared Alfonso EspadaiD· 1 shared An-Ping Yu· 1 shared Anna Pavlů· 1 shared David B. WainscottiD· 1 shared Eamonn ReadingiD· 1 shared Howard B. BroughtoniD· 1 shared Jan PrchaliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

Aaron D. Showalter

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 4, 2026

Structural dynamics underlying agonist activation of a GLP-1R-Gs precoupled complex

Jakub Sýs, Joseph D Ho, Aaron D. Showalter…·Eamonn Reading

This study uses hydrogen-deuterium exchange mass spectrometry to analyze how non-peptide agonists and endogenous ligands modulate structural dynamics in a pre-coupled GLP-1R-Gs complex, revealing patterns linked to receptor activation.

DOI 10.64898/2026.08.03.742488

humanexperimental assay

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Molecular BiologyeLifePeer-reviewedMar 22, 2024

A myristoyl switch at the plasma membrane triggers cleavage and oligomerization of Mason-Pfizer monkey virus matrix protein

Markéta Častorálová, Jakub Sýs, Jan Prchal…·Tomáš Ruml

The paper shows that myristoyl exposure in M-PMV matrix protein triggers structural changes leading to efficient cleavage of Gag polyprotein.

7 citations

experimental assay

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