Author

Alfonso Espada

ORCID 0000-0002-8301-1201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Aaron D. Showalter· 1 shared An-Ping Yu· 1 shared David B. WainscottiD· 1 shared Eamonn ReadingiD· 1 shared Howard B. BroughtoniD· 1 shared Jakub SýsiD· 1 shared Joseph D Ho· 1 shared Kyle W. SloopiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Aaron D. Showalter

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1 paper

Recent·Most cited

Structural dynamics underlying agonist activation of a GLP-1R-Gs precoupled complex

Jakub Sýs, Joseph D Ho, Aaron D. Showalter, An-Ping Yu, David B. Wainscott, Veronica Laos, Howard B. Broughton, Kyle W. Sloop, Alfonso Espada, Eamonn Reading

This study uses hydrogen-deuterium exchange mass spectrometry to analyze how non-peptide agonists and endogenous ligands modulate structural dynamics in a pre-coupled GLP-1R-Gs complex, revealing patterns linked to receptor activation.

bioRxiv · Aug 4, 2026 · PreprintBiochemistry