Paul Grevitt

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

This study shows that C-terminal HaloTag fusion to AGO2 impairs its function and localization, highlighting the need to validate tagging strategies.

This study identifies CoAsy as a regulator of HIF signalling in TNBC, showing its loss stabilizes HIF-1 and HIF-2 and correlates with poor patient outcomes.

This study identifies GPX4 as a therapeutic target in LIMD1-deficient lung cancer by showing its role in ferroptosis susceptibility.

This study shows that LIMD1 loss in lung cancer increases PD-L1 expression, promoting immune evasion and enhancing response to immune checkpoint inhibitors.