Author
New York University Abu DhabiORCID 0000-0001-8226-4816Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Elena Magnani, Charlene Chen, Filippo Macchi…·Kirsten C. Sadler
This study shows UHRF1 overexpression in zebrafish hepatocytes leads to diverse senescent states with different Tp53 dependencies and responses to senolytic drugs.
Jacopo Biotti, Livio Muccillo, Filippo Macchi…·Ian Marc Bonapace
The paper identifies a UHRF1-EM framework linking DNA methylation, developmental chromatin states, and prognosis in gastric, renal, and adrenal cancers, showing context-dependent prognostic associations.
Elena Magnani, Filippo Macchi, Tijana Randic…·Kirsten C. Sadler
The paper shows that high UHRF1 levels in zebrafish hepatocytes cause epigenetic disordering, leading to stemness, senescence escape, and tumor heterogeneity in hepatocellular carcinomas.
Filippo Macchi, Eric Edsinger, Kirsten C. Sadler
The paper identifies conserved epigenetic regulators in cephalopods and shows dynamic DNA methylation patterns across tissues.
Anjana Ramdas Nair, Priyanka Lakhiani, Chi Zhang…·Kirsten C. Sadler
The paper identifies Atf6 target genes and shows that a permissive epigenetic landscape allows distinct transcriptional responses to Atf6 activation in liver stress conditions.