Kirsten C. Sadler

This study shows UHRF1 overexpression in zebrafish hepatocytes leads to diverse senescent states with different Tp53 dependencies and responses to senolytic drugs.

This study shows that Eed deficiency in hepatocytes causes liver injury, fibrosis, and altered regeneration by disrupting H3K27me3 regulation of pro-regenerative genes.

The paper shows that high UHRF1 levels in zebrafish hepatocytes cause epigenetic disordering, leading to stemness, senescence escape, and tumor heterogeneity in hepatocellular carcinomas.

The paper shows DNA hypomethylation in zebrafish leads to Cdk4/6 activation, ATR-mediated replication stress, and cell cycle arrest, which restricts liver growth.

This paper shows that As3mt regulates hepatic energy metabolism independently of arsenic detoxification, leading to mitochondrial dysfunction and fatty liver in zebrafish mutants.

The paper identifies conserved epigenetic regulators in cephalopods and shows dynamic DNA methylation patterns across tissues.

The paper identifies Atf6 target genes and shows that a permissive epigenetic landscape allows distinct transcriptional responses to Atf6 activation in liver stress conditions.

This study improves zebrafish transcriptome annotation using long-read sequencing, identifying novel transcripts and isoforms, and validating them through computational and experimental methods.