Charlene Chen

This study shows UHRF1 overexpression in zebrafish hepatocytes leads to diverse senescent states with different Tp53 dependencies and responses to senolytic drugs.

This study shows that Eed deficiency in hepatocytes causes liver injury, fibrosis, and altered regeneration by disrupting H3K27me3 regulation of pro-regenerative genes.

The paper shows that high UHRF1 levels in zebrafish hepatocytes cause epigenetic disordering, leading to stemness, senescence escape, and tumor heterogeneity in hepatocellular carcinomas.