Cancer BiologybioRxivPreprint
Fetal context conveys heritable protection against MLL-rearranged leukemia that depends on MLL3
Jonny Mendoza‐Castrejon, Wei Yang, Elisabeth Denby…·Jeffrey A. Magee
The paper shows fetal exposure to MLL::ENL creates a heritable leukemia-resistant state by altering hematopoietic progenitor behavior, which can be overcome by MLL3 inactivation or cooperating mutations.
DOI 10.1101/2025.03.11.642680