Author

Hong Xu

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Edward B. LeeiD· 2 shared Alexander Adrian-Hamazaki· 1 shared Amelia RichteriD· 1 shared Andy Mungall· 1 shared Angelina Baltazar· 1 shared Armaghan SarvariD· 1 shared BaRun Kim· 1 shared Beixi WangiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Edward B. LeeORCID

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Author profile →

4 papers

Recent·Most cited

Chromosomal mutational signatures of DNA damaging agents at single cell resolution

Mirela Andronescu, Alexander Adrian-Hamazaki, Damian Yap, William Daniels, Armaghan Sarvar, Elena Zaikova, Benjamin Furman, Vinci Au, Amelia Richter, Michael Van Vliet, Caroline Baril, Beixi Wang, Sean Beatty, Farhia Kabeer, Ciara H. O’Flanagan, , Samuel A. J. R. Aparicio

This paper develops a framework to analyze chromosomal mutational patterns at single-cell resolution, revealing drug-induced mutational signatures in human tissues.

bioRxiv · Sep 7, 2026 · PreprintCancer Biology

Repositioning of polyubiquitin alters the pathologic tau filament structure

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich, Courtney L. Smith, Hong Xu, Angelina Baltazar, Sacha P. Salphati, Lakshmi N. Changolkar, Kevt’her Hoxha, Bin Zhang, Caroline M. O’Rourke, George M. Burslem, Virginia M.‐Y. Lee, Yi‐Wei Chang, Edward B. Lee

This study shows that polyubiquitin repositioning affects tau filament structure in tauopathies, altering their seeding activity in mice.

Nature Structural & Molecular Biology · Aug 31, 2026Peer-reviewedNeuroscience

Exome Reanalysis Identifies Novel Candidate Genes Associated with Congenital Anomalies of the Kidney and Urinary Tract in China

Huaping Sun, C N Wang, Wentao Zhang, Mingji Deng, Qian Shen, Jianhua Mao, Qing Sun, Huimin Luo, Huijun Shen, Jingjing Wang, Dandan Xin, Yan Zhou, Miaomiao Li, Yihui Zhai, Ying Cao, , Shaohua Fan

This study reanalyzes exome sequencing data from Chinese CAKUT patients to identify four novel candidate genes associated with kidney and urinary tract anomalies.

medRxiv · Feb 9, 2026 · PreprintGenetic & Genomic Medicine

Tau Aggregation Results in an Impaired Ability to Counteract Microtubule Destabilization via Specific Combinatorial Tau Phosphorylation Patterns

Nima N. Naseri, Tian Xu, Ibrahim Saleh, Sapanna Chantarawong, Steven M. Patrie, Neil L. Kelleher, Manu Sharma, Hong Xu, Edward B. Lee, Ophir Shalem, Elizabeth R. Rhoades

This study shows that tau phosphorylation patterns influence microtubule stability, with specific phosphorylations impairing tau's ability to counteract destabilization, suggesting phosphorylation may respond to, rather than precede, MT instability.

bioRxiv · Aug 9, 2025 · PreprintNeuroscience