Jin He

The paper integrates bulk RNA-seq data from multiple studies to identify reproducible matrix-immune gene expression signatures in IPF.

This study shows that KDM6B promotes postnatal oligodendrocyte development and cortical myelination by regulating Sox10 expression through H3K27me3 demethylation.

This study shows that cocaine exposure increases calreticulin in the ventral hippocampus via ΔFosB, reducing excitability in the vHPC-NAc circuit and promoting cocaine seeking and reward.

This study identifies SMYD5 as a regulator of the mild hypothermia response through histone modifications, revealing its role in temperature-dependent gene repression.

This study analyzes time-resolved biochemical and immune measurements from 27 astronauts before, during, and after spaceflight to identify physiological changes linked to spaceflight conditions.

The paper uses differential network analysis to study gene expression changes in response to vaccination and drug treatment, identifying pathway activations consistent with the mechanisms of action.

This study shows that deleting the autism risk gene Ash1l in mice leads to neural hyperactivity and related behavioral and cognitive deficits.

This study shows that KDM2B dysfunction leads to neural stem cell senescence and ASD/ID-like behaviors in mice, linking 12q24.31 microdeletions to neurodevelopmental disorders.

This study shows that loss of ASH1L in developing mouse brains leads to autistic-like behaviors and cognitive impairments, establishing a causal link between ASH1L mutations and ASD/ID.

This study tracks saliva omics changes over time in response to immune perturbation, revealing broad immune responses in both innate and adaptive timeframes.

This study shows FGF/ERK signaling regulates PRC2 occupancy in mESCs via JARID2 and reveals transcription factors drive bivalent gene de-repression independently of PRC2 occupancy.