Yan Wu

An atlas of healthy and injured cell states and niches in the human kidney

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas

The paper develops a method to screen oncogenic genes across multiple lineages using teratomas and identifies drivers of proliferation in specific cell types.

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse model

This study shows that loss of ASH1L in developing mouse brains leads to autistic-like behaviors and cognitive impairments, establishing a causal link between ASH1L mutations and ASD/ID.

Revealing the transcription factor regulatory context of human specific cortical development using single-cell multi-omics

The paper uses single-cell multi-omics to analyze HARs and HGEs in fetal human brain development, identifying regulatory networks and key transcription factors involved in human-specific neurodevelopment.

Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage

This paper presents a computational strategy to optimize spectral library size for DIA-MS data, improving peptide and protein identification rates in colorectal and carcinoma samples.

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells

This study shows FGF/ERK signaling regulates PRC2 occupancy in mESCs via JARID2 and reveals transcription factors drive bivalent gene de-repression independently of PRC2 occupancy.

Visualizing and interpreting single-cell gene expression datasets with Similarity Weighted Nonnegative Embedding

The paper introduces SWNE, a method for visualizing single-cell gene expression data that improves local and global structure preservation compared to t-SNE.