Yuen Gao

Ribosome Heterogeneity in Development and Disease

The paper calculates ribosome protein stoichiometry ratios across tissues and developmental stages, revealing functional ribosome heterogeneity in health and disease.

Neural hyperactivity is a core pathophysiological change induced by deletion of an autism risk gene Ash1l in the mouse brain

This study shows that deleting the autism risk gene Ash1l in mice leads to neural hyperactivity and related behavioral and cognitive deficits.

Impaired KDM2B-mediated PRC1 recruitment to chromatin causes neural stem cell senescence and ASD/ID-like behavioral deficits

This study shows that KDM2B dysfunction leads to neural stem cell senescence and ASD/ID-like behaviors in mice, linking 12q24.31 microdeletions to neurodevelopmental disorders.

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse model

This study shows that loss of ASH1L in developing mouse brains leads to autistic-like behaviors and cognitive impairments, establishing a causal link between ASH1L mutations and ASD/ID.

Cell signaling coordinates global Polycomb Repressive Complex 2 recruitment and gene expression in murine embryonic stem cells

This study shows FGF/ERK signaling regulates PRC2 occupancy in mESCs via JARID2 and reveals transcription factors drive bivalent gene de-repression independently of PRC2 occupancy.