Junjie U. Guo

The paper shows that C9ORF72 repeat expansions cause aberrant splicing, leading to exonization and altered RNA processing in ALS/FTD.

The paper shows that alternative translation initiation sites produce proteoforms with distinct localization and functions, specifically in synaptic organizers like NPR and C1q-like proteins.

The paper identifies eIF2A as a host factor that enhances SARS-CoV-2 -1 ribosomal frameshifting through direct RNA interaction.

The paper identifies stress-induced RNA G-quadruplexes in human cells and shows they regulate mRNA stability and stress response.

The paper systematically generates tandem repeats to identify sequence features driving RNA aggregation, finding multivalent base-pairing as a key mechanism.

This study identifies merafloxacin as a -1 PRF inhibitor that impedes SARS-CoV-2 replication in vitro.

This study shows that C9orf72 dipeptide repeats inhibit UPF1-mediated RNA decay without requiring stress granule formation, contributing to RNA accumulation in c9ALS/FTD.