Author

Katherine R. Sadleir

Northwestern UniversityORCID 0000-0001-8310-841XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Robert J. VassariD· 3 shared Adriana FerreiraiD· 1 shared Alexis D. RickmaniD· 1 shared Amira AffanehiD· 1 shared Ammaarah W. Khatri· 1 shared Andrea E. MurmanniD· 1 shared Andrew Octavian SasmitaiD· 1 shared Ashley Haluck-KangasiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Robert J. VassarORCID

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3 papers

Recent·Most cited

NeuroscienceAlzheimer s Research & TherapyPeer-reviewedJun 3, 2026

Neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD Alzheimer's disease model mice

Katherine R. Sadleir, Karen P Gomez, Sidhanth Chandra…·Robert J. Vassar

This study shows neuronal overexpression of Nrf2 reduces dystrophic neurites in 5XFAD mice by lowering BACE1 and other proteins in these structures.

DOI 10.1186/s13195-026-02097-2

mousebulk RNA-seq

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NeuroscienceNature NeurosciencePeer-reviewedAug 5, 2024

Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer's disease

Andrew Octavian Sasmita, Constanze Depp, T. I. Nazarenko…·Klaus‐Armin Nave

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

118 citationstop 1%

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NeurosciencebioRxivPreprintSep 8, 2022

Death Induced by Survival gene Elimination (DISE) is correlated with neurotoxicity in Alzheimer's disease and aging

Bidur Paudel, Si‐Yeon Jeong, Carolina Peña-Martinez…·Marcus E. Peter

The paper identifies DISE, an RNA interference-mediated cell death mechanism, as correlated with neurotoxicity in Alzheimer's disease and aging, showing shifts in 6mer seed toxicity in different models.

5 citations

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