Author

Graeme C.M. Smith

Artios Pharma Limited (United Kingdom)ORCID 0000-0001-8320-4057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Abeer M. ShaabaniD· 1 shared Alessandro CicconiiD· 1 shared Amber Stiby· 1 shared Anna Munsey· 1 shared Asmita Thapa· 1 shared Aurora CeruttiiD· 1 shared Bethany Rebekah Hill· 1 shared Bohdana-Myroslava Briantseva· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Abeer M. ShaabanORCID

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2 papers

Recent·Most cited

Cancer BiologyScience AdvancesPeer-reviewedJun 12, 2026

SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy

Gonzalo Rodríguez‐Berriguete, Purusotha Thambiayah, Alessandro Cicconi…·Geoff Stuart Higgins

The paper identifies SHLD2 loss as a vulnerability that enhances radiosensitisation when combined with Polθ inhibition in cancer cells.

DOI 10.1126/sciadv.aeb4508

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 15, 2025

MYBL2 maintains stemness and promotes theta-mediated end joining in triple negative breast cancer

Rachel Bayley, Anna Munsey, Suman Ahmed…·Paloma García

This study shows MYBL2 maintains stemness and promotes theta-mediated end joining in TNBC, and identifies Pol{theta}/ATR inhibition as a therapeutic strategy.

DOI 10.1101/2025.04.15.648875

humanbulk RNA-seq

𝕏 PostBluesky