Author

Tyler R. Huycke

Harvard UniversityORCID 0000-0001-8328-5061Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Assay:imaging· 1 Organism:Xenopus· 1

Frequent Co-Authors

Adam C MartiniD· 1 shared Ali Kalantari· 1 shared Andrea G Laboy-Figueroa· 1 shared Ann L MilleriD· 1 shared Ashley Shahi· 1 shared Babli AdhikaryiD· 1 shared ChangHee LeeiD· 1 shared Christopher S. McGinnisiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

Adam C MartinORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 3, 2026

Calcium and actomyosin pulses drive tricellular zipping to remodel epithelial cell-cell junctions and facilitate cell packing

Babli Adhikary, Xinran O Zhao, Ashley Shahi…·Ann L Miller

The paper identifies tricellular zipping as a mechanism for epithelial junction remodeling, driven by calcium and actomyosin pulses, and shows its role in cell packing across Xenopus, mouse, and Drosophila embryos.

DOI 10.64898/2026.10.30.763104

Xenopusmouse

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Developmental BiologyDevelopmental CellPeer-reviewedAug 7, 2024

Hox genes modulate physical forces to differentially shape small and large intestinal epithelia

Hasreet K. Gill, Sifan Yin, Nandan L. Nerurkar…·Clifford James Tabin

This study shows Hoxd13 regulates hindgut morphogenesis through the TGFβ pathway by altering mesenchymal biomechanics.

22 citations

mouseexperimental assay

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Developmental BiologyCellPeer-reviewedMay 22, 2024

Patterning and folding of intestinal villi by active mesenchymal dewetting

Tyler R. Huycke, Teemu J. Häkkinen, Hikaru Miyazaki…·Zev J. Gartner

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

92 citationstop 1%

mouseexperimental assay

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