Author

Hikaru Miyazaki

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Dimitry Popov· 3 shared Martin Borch JenseniD· 3 shared Vishwaraj SontakeiD· 3 shared Smitha Shambhu· 2 shared Adam H. BiedrzyckiiD· 1 shared Aleksandra TataiD· 1 shared Ali Kalantari· 1 shared Amber LimiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPathology

Dimitry Popov

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Multispecies, Modality-Agnostic Scalable In Vivo Mosaic Screening Platform for Therapeutic Target Discovery

Vishwaraj Sontake, Vinay K. Kartha, Neety Sahu, Daniel Fuentes, Linda Chio, Hikaru Miyazaki, Jingshu Chen, Arnav Gupta, Jesi Nonora, Arthi Vaidyanathan, Smitha Shambhu, Gayathri Donepudi, Carmen Le, Lianna Fung, Amber Lim, , Martin Borch Jensen

The paper presents an in vivo screening platform for validating therapeutic targets across species and modalities, identifying functional targets in fibrosis and osteoarthritis models.

bioRxiv · Mar 4, 2026 · PreprintGenomics

Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis

Shuang Wu, Ian Driver, Meihui Luo, Hikaru Miyazaki, Smitha Shambhu, Dimitry Popov, Liyuan Yang, Jing Wang, Jia Ma, Junfeng Guo, Jarron Atha, Aleksandra Tata, Eric A. Hoffman, Yujiong Wang, Purushothama Rao Tata, , Xiaoming Liu

This study shows that a bleomycin-induced lung injury model in ferrets shares key pathophysiological, cellular, and molecular features with human idiopathic pulmonary fibrosis, suggesting its use for IPF research.

npj Regenerative Medicine · Nov 21, 2025Peer-reviewedPathology

Wilms tumor 1 impairs apoptotic clearance of fibroblasts in distal fibrotic lung lesions

Harshavardhana H. Ediga, Chanukya P. Vemulapalli, Vishwaraj Sontake, Pradeep Kumar Patel, Hikaru Miyazaki, Dimitry Popov, Martin Borch Jensen, Anil Goud Jegga, Steven Kenneth Huang, Christoph Englert, Andreas Schedl, Nishant Gupta, Francis X. McCormack, Satish Kumar Madala

This study shows WT1 promotes fibroblast survival and ECM production in IPF by impairing apoptotic clearance.

Journal of Clinical Investigation · Jun 10, 2025Peer-reviewedPathology

Patterning and folding of intestinal villi by active mesenchymal dewetting

Tyler R. Huycke, Teemu J. Häkkinen, Hikaru Miyazaki, Vasudha Srivastava, Emilie Barruet, Christopher S. McGinnis, Ali Kalantari, Jake Cornwall-Scoones, Dedeepya Vaka, Qin Zhu, Hyunil Jo, Roger Oria, Valerie Marie Weaver, William F. DeGrado, Matt W. Thomson, , Zev J. Gartner

This study identifies an active mechanical mechanism involving PDGFRA+ mesenchymal cells that pattern and fold intestinal villi through myosin II-dependent forces and matrix metalloproteinase-mediated tissue fluidization.

Cell · May 22, 2024Peer-reviewedDevelopmental Biology