Cancer BiologyJournal of Clinical InvestigationPeer-reviewed
A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.
Giulio Verna, Stefania De Santis, Bianca N. Islam…·Fabio Cominelli
This study shows that a Muc2 mutation in Winnie mice leads to colitis-associated tumorigenesis driven by the gut microbiome and metabolome, with SPF conditions promoting severe disease and CAC.
3 citations