Author

Bianca N. Islam

Case Western Reserve UniversityORCID 0000-0002-2124-1028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Fabio CominelliiD· 2 shared Theresa T. PizarroiD· 2 shared Alka TomariD· 1 shared Bruce W ArmstrongiD· 1 shared Carlo De SalvoiD· 1 shared Danilo LicastroiD· 1 shared Eduardo SommellaiD· 1 shared Emily N. MilleriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMolecular Biology

Fabio CominelliORCID

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2 papers

Recent·Most cited

Epithelial and stromal remodeling in murine Crohn's disease-like ileitis

Katherine C. Letai, Bianca N. Islam, Paola Menghini, Carlo De Salvo, Neha S Khandekar, Bruce W Armstrong, Alka Tomar, Kimberly Curry, Theresa T. Pizarro, Paul J. Tesar, Marissa A. Scavuzzo, Fabio Cominelli

The paper uses snRNA-seq to analyze ileitis in SAMP mice, identifying stromal and epithelial transcriptional changes that mirror human CD, including Igf1 and Pcsk6 expression.

bioRxiv · Nov 8, 2025 · PreprintMolecular Biology

A missense mutation in Muc2 promotes gut microbiome- and metabolome-dependent colitis-associated tumorigenesis.

Giulio Verna, Stefania De Santis, Bianca N. Islam, Eduardo Sommella, Danilo Licastro, Liangliang Zhang, Fabiano De Almeida Celio, Emily N. Miller, Fabrizio Merciai, Vicky Caponigro, Wei Xin, Pietro Campiglia, Theresa T. Pizarro, Marcello Chieppa, Fabio Cominelli

This study shows that a Muc2 mutation in Winnie mice leads to colitis-associated tumorigenesis driven by the gut microbiome and metabolome, with SPF conditions promoting severe disease and CAC.

Journal of Clinical Investigation · Nov 6, 2025Peer-reviewedCancer Biology