Dmitry Aleksandrovich Skvortsov

Estimation of splicing metrics for NMD-sensitive transcripts

The paper develops a framework to correct splicing metric estimation for NMD-sensitive transcripts using statistical models and linear fractional transformations.

Novel examples of NMD escape through alternative intronic polyadenylation

The paper identifies NMD escape through alternative intronic polyadenylation by analyzing GTEx data and demonstrates tissue-specific isoform switches in several genes.

BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing

This study identifies conserved RNA structures in BRD2 and BRD3 genes that regulate unproductive splicing through poison exons, showing convergent evolution of splicing control mechanisms.

Tissue-specific regulation of gene expression via unproductive splicing

The paper identifies tissue-specific unproductive splicing events (USEs) regulated by RBPs using RNA-seq and RBP footprinting data from GTEx.

RNA in situ conformation sequencing reveals novel long-range RNA structures with impact on splicing

This study uses RIC-seq to identify long-range RNA structures that influence alternative splicing in human genes.

Conserved long-range base pairings associated with pre-mRNA processing of human protein-coding genes

The paper identifies 916,360 conserved long-range RNA structures in the human transcriptome and shows their association with pre-mRNA processing.

Multiple competing RNA structures dynamically control alternative splicing in human ATE1 gene

The paper identifies two RNA structure modules that dynamically regulate mutually exclusive splicing in the ATE1 gene, revealing their functional roles in splicing outcomes.