Dmitri Davidovich Pervouchine

This study compares transcriptomic profiles of penile and vulvar lichen sclerosus to identify shared deregulated genes and potential biomarkers.

The paper develops a framework to correct splicing metric estimation for NMD-sensitive transcripts using statistical models and linear fractional transformations.

The paper identifies NMD escape through alternative intronic polyadenylation by analyzing GTEx data and demonstrates tissue-specific isoform switches in several genes.

The paper identifies conserved intronic splicing regulatory elements in SCN gene paralogs and shows their role in mutually exclusive exon inclusion through RNA structure and Rbfox2 interactions.

The paper quantifies NMD efficiency using RNA-seq data and shows its variation across tissues and tumors, revealing global deregulation in cancer.

The paper introduces TransCistor, a framework to identify cis-regulatory lncRNAs with controlled false discovery rates, finding that only a minority of lncRNAs are cis-acting, primarily as activators.

This study identifies conserved RNA structures in BRD2 and BRD3 genes that regulate unproductive splicing through poison exons, showing convergent evolution of splicing control mechanisms.

RNAcontacts detects RNA-RNA contacts from proximity ligation assays using a two-pass alignment approach to improve sensitivity and specificity.

The paper identifies tissue-specific unproductive splicing events (USEs) regulated by RBPs using RNA-seq and RBP footprinting data from GTEx.

This study uses RIC-seq to identify long-range RNA structures that influence alternative splicing in human genes.

The paper identifies intronic polyadenylation sites and shows they are more common than exonic ones, suggesting splicing counteracts premature termination at these sites.

The paper analyzes RNA-seq data from TCGA to assess stemness and proliferation gene expression across tumor types, finding high heterogeneity and questioning the use of stemness markers in cancer diagnostics.

The paper identifies 916,360 conserved long-range RNA structures in the human transcriptome and shows their association with pre-mRNA processing.

The paper presents an extended catalogue of tandem alternative splice sites in human tissues, analyzing their expression and regulation.

The paper identifies two RNA structure modules that dynamically regulate mutually exclusive splicing in the ATE1 gene, revealing their functional roles in splicing outcomes.

The paper identifies five major cell types based on transcriptional programs in human tissues and shows their composition correlates with tissue morphology and disease.

The paper updates gene annotations for 191 epilepsy genes, reclassifying variants and identifying new de novo SCN1A variants in Dravet syndrome patients.

The paper identifies novel autoregulatory feedback loops where RNA-binding proteins regulate their own expression via alternative splicing and nonsense-mediated mRNA decay.