Author

John V. Williams

University of PittsburghORCID 0000-0001-8377-5175Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam BrynesiD· 1 shared Isabella E. Bosco· 1 shared Jennifer E. JonesiD· 1 shared Jie LaniD· 1 shared Megan Culler FreemaniD· 1 shared Mikal A. Woods AcevedoiD· 1 shared Sarah Maya· 1 shared Terence S. DermodyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 22 mutual co-author links

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1 shared paperImmunology

Adam BrynesORCID

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2 papers

Recent·Most cited

MicrobiologyJournal of Clinical InvestigationPeer-reviewedJun 3, 2025

Immune cells promote paralytic disease in mice infected with enterovirus D68

Mikal A. Woods Acevedo, Jie Lan, Sarah Maya…·Terence S. Dermody

This study shows that immune cell infiltration into the spinal cord promotes paralysis in mice infected with EV-D68, suggesting immune cell targeting as a therapeutic strategy.

9 citationstop 3%

mouseexperimental assay

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ImmunologyJournal of VirologyPeer-reviewedOct 16, 2024

Human metapneumovirus SH protein promotes JAK1 degradation to impair host IL-6 signaling

Adam Brynes, Yu Zhang, John V. Williams

This paper identifies the HMPV SH protein as a factor that inhibits IL-6 signaling by promoting JAK1 proteasomal degradation, contributing to immune evasion.

25 citationstop 2%

humanproteomics

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