Gordon M. Keller

This paper generates engraftable vascular progenitors from human pluripotent stem cells that form functional vessels and improve perfusion in ischemic tissue.

This study generates functional B cells from human pluripotent stem cells, recapitulating B lymphopoiesis stages and enabling plasma cell differentiation for therapeutic applications.

This study identifies dysregulated TGFβ-ERK signaling as a driver of aberrant extracellular matrix production in Noonan syndrome-associated pulmonary valve stenosis using iPSC models and patient tissue.

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

The paper identifies fetal pancreatic macrophage subsets and shows their role in promoting endocrine cell differentiation and tissue engraftment.

The paper evaluates the ability of human embryonic stem cell-derived articular cartilage to repair osteochondral defects in rat knees.