Claire T. Friel

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

A synthetic ancestral Kinesin-13 depolymerises microtubules faster than any natural depolymerising kinesin

The paper creates a synthetic ancestral Kinesin-13 motor domain and shows it depolymerises microtubules faster than any known natural depolymerising kinesin.

Introduction of Kinesin-13 family specific residues increases the microtubule end residence time of a Kinesin-1

This paper introduces Kinesin-13 family-specific residues into Kinesin-1, increasing its microtubule-end residence time by 2-4-fold but not conferring depolymerisation activity.