Didier Busso

This study identifies lamin B1 as a regulator of separase activity during mitosis, showing that lamin B1 depletion or overexpression disrupts chromosome separation and centrosome stability.

This study shows that neonatal mouse recipients are more permissive than adult mice for ETO2::GLIS2-driven leukemogenesis from human cord blood CD34+ cells.

The paper shows KIF2C forms condensates during mitosis that concentrate PLK1 and phosphorylated BRCA2 at kinetochore microtubules, enhancing their kinase activity and attachment stability.

The paper reveals that Rap1 inhibits Ku's NHEJ function at telomeres by obstructing Ku's inward translocation, preventing promiscuous repair.

This study identifies an 85-residue segment of Rad52 that facilitates Rad51 filament formation and stability through structural and functional analyses in yeast.

This study shows 53BP1 interacts with RNA primers from Okazaki fragments during DNA replication, supporting their processing and highlighting an RNA-protein interaction at replication forks.

The paper shows that dense Rap1 arrays block DNA loop extrusion by condensin in yeast, acting as contact insulators and affecting dicentric chromosome resolution.

This study shows that Sir3 promotes NHEJ by inhibiting Sae2-dependent resection through physical interaction, independent of its heterochromatin function.

The paper shows MEIOB and SPATA22 interact with RPA to support meiotic recombination by modifying RPA-coated ssDNA and stabilizing recombination intermediates.