Upregulation of TRPM3 drives hyperexcitability in nociceptors innervating inflamed tissue.
Marie Mulier, Nele Van Ranst, Nikky Corthout, Sebastian Munck, Pieter Vanden Berghe, Joris Vriens, Thomas Voets, Lauri Moilanen
This study shows that TRPM3 upregulation in nociceptors contributes to heat hyperalgesia during inflammation, with pharmacological inhibition reducing TRPV1 and TRPA1 responses.
bioRxiv · Apr 30, 2020 · PreprintNeuroscience