Joris Vriens

Stereoselectivity and functional plasticity of a common ligand-binding pocket in TRPM3

This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.

Investigating endometriosis development and endometriosis-related pain over time and in relation to estrogen in a laparoscopic mouse model

This study investigates endometriosis development and associated pain in a mouse model, examining the effects of estrogen on lesion progression over time.

Osmolar modulation drives reversible cell cycle exit and human pluripotent cell differentiation via NF-κB and WNT signaling

This study shows that hyperosmolar conditions induce cell cycle exit and differentiation in pluripotent cells through NF-κB and WNT signaling pathways.

TRPM3 as novel target to alleviate acute oxaliplatin-induced peripheral neuropathic pain

This study identifies TRPM3 as a potential therapeutic target for acute oxaliplatin-induced neuropathic pain by showing its role in pain behaviors and neuronal activity.

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

This study investigates two TRPM3 mutations linked to DEE, showing they cause gain of function through altered channel gating and increased sensitivity to neurosteroids and heat.

Upregulation of TRPM3 drives hyperexcitability in nociceptors innervating inflamed tissue.

This study shows that TRPM3 upregulation in nociceptors contributes to heat hyperalgesia during inflammation, with pharmacological inhibition reducing TRPV1 and TRPA1 responses.

The sensory coding of warm perception

The paper shows mice can discriminate warm temperatures without dedicated thermoreceptors, using polymodal C-fibers and central circuits that integrate inputs from multiple afferents.