Sebastian Munck

A high-performance end-to-end 3D CLEM processing workflow for facilities

This paper presents an end-to-end 3D CLEM processing pipeline that integrates existing and new tools to streamline analysis, improve reproducibility, and support facility-scale use.

Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

Upregulation of TRPM3 drives hyperexcitability in nociceptors innervating inflamed tissue.

This study shows that TRPM3 upregulation in nociceptors contributes to heat hyperalgesia during inflammation, with pharmacological inhibition reducing TRPV1 and TRPA1 responses.