Thomas Voets

This paper develops a high-throughput 3D β-cell spheroid platform to measure Ca2+ oscillations and insulin release in response to glucose and compounds.

This study identifies stereoselectivity and functional plasticity in the TRPM3 ligand-binding pocket using cryo-EM and functional analyses, revealing how ligand structure affects channel gating.

This study shows rapamycin directly activates TRPM8 ion channels by binding to a novel site, distinct from known agonists, and highlights implications for drug development and research methods.

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

This study identifies TRPM3 as a potential therapeutic target for acute oxaliplatin-induced neuropathic pain by showing its role in pain behaviors and neuronal activity.

This study investigates two TRPM3 mutations linked to DEE, showing they cause gain of function through altered channel gating and increased sensitivity to neurosteroids and heat.

This study shows that TRPM3 upregulation in nociceptors contributes to heat hyperalgesia during inflammation, with pharmacological inhibition reducing TRPV1 and TRPA1 responses.

The paper shows mice can discriminate warm temperatures without dedicated thermoreceptors, using polymodal C-fibers and central circuits that integrate inputs from multiple afferents.