Thomas Thum

This study examines natural cardiovascular aging in non-human primates, finding histological and molecular changes associated with aging, including fibrosis, inflammation, and atherosclerosis.

This study investigates the molecular mechanism of cardiac myosin dysfunction caused by the A57D mutation in MLC1v using single-molecule analysis and computational modeling.

This study shows that modGLA mRNA therapy reverses Fabry disease phenotypes in human iPSC-derived cardiomyocytes by restoring enzyme activity and normalizing molecular alterations.

This study demonstrates that modRNA hTERT treatment reduces fibrosis markers and senescence in human lung cells and tissue slices.

This study shows SGLT2 inhibitors reduce endothelial to mesenchymal transition and cardiac fibroblast activation through effects on mitochondrial respiration, actin cytoskeleton, and specific transporters.

This study identifies NEAT1 as a calcium-regulated lncRNA that promotes cardiac hypertrophy by modulating GRK2 expression and transcriptional regulation in cardiomyocytes.