Author

Francesca Aguiló

Umeå UniversityORCID 0000-0002-2374-2045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2

Frequent Co-Authors

André MateusiD· 3 shared Kanchan KumariiD· 3 shared Ángel RomániD· 2 shared Carlos Peula· 2 shared Erik DassiiD· 2 shared EVA LUNDIN· 2 shared Jonathan D. GilthorpeiD· 2 shared Manel EstelleriD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersMolecular Biology

André MateusORCID

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Author profile →

4 papers

Recent·Most cited

METTL3 regulates exocytosis independently of m6A

Margalida Esteva-Socias, Devi Prasad Bhattarai, Cyrinne Achour, Poonam Baidya, Kumari, Kanchan, Gaia Fontanari, Kerstin Seier, Hudson P. Pace, Sandhya Malla, Shaochun Zhu, EVA LUNDIN, Cathrine Broberg Vågbø, Marta Bally, Vinay Swaminathan, André Mateus, , Francesca Aguiló

This study identifies a non-catalytic role of METTL3 in regulating exocytosis and the cancer secretome through stabilization of EXOC7.

DiVA at Umeå University (Umeå University) · Jan 1, 2026Peer-reviewedMolecular Biology

METTL3-mediated m6A modification of DNMT1 enhances ovarian cancer progression

Kanchan Kumari, Iván Pérez-Núñez, Aleix Noguera‐Castells, Raquel Pluvinet, Carlos Peula, Annika Patthey, Ghazala Naz Khan, Kinga Pajdzik, Ángel Román, Erik Dassi, Chuan He, Eva Lundin, Manel Esteller, Toni Celià-Terrassa, Francesca Aguiló

This study identifies METTL3-mediated m6A modification of DNMT1 as a driver of ovarian cancer progression by enhancing DNMT1 translation and suppressing tumor suppressors.

bioRxiv · Sep 10, 2025 · PreprintCancer Biology

Fibrillarin shapes oncogenic protein pools and ribosomal composition in triple-negative breast cancer

Paula Groza, Kanchan Kumari, Johanna Schott, Margalida Esteva-Socias, Eliana Destefanis, Carlos Peula, Chloe Williams, Virginie Marchand, Pernilla Wikström, Rebecca Wiberg, Ana Bosch Campos, Jonathan D. Gilthorpe, Bogdan Pop, André Mateus, Yuri Motorin, , Francesca Aguiló

This study shows that Fibrillarin regulates oncogenic protein pools and ribosomal composition in triple-negative breast cancer by modulating rRNA methylation and RPS28 levels.

bioRxiv · Mar 21, 2025 · PreprintMolecular Biology

The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells

Sandhya Malla, Kanchan Kumari, Carlos Martinez‐Gamero, Carlos Antonio García-Prieto, Stephanie Stransky, Jonatan Caroli, Damiana Álvarez‐Errico, Paulina Avovome Saiki, Weiyi Lai, Cong Lyu, Jonathan D. Gilthorpe, Hailin Wang, Simone Sidoli, Andrea Mattevi, André Mateus, , Francesca Aguiló

This study shows that LSD1's non-catalytic function regulates DNA methylation in mouse ESCs by controlling UHRF1 and DNMT1 stability through USP7 interaction.

bioRxiv · Jun 29, 2023 · PreprintMolecular Biology