Author

Christopher R. D'Angelo

4Division of Hematology and Oncology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska.ORCID 0000-0001-8456-0889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Audrey L. SmithiD· 2 shared Dalia El‐GamaliD· 2 shared Sydney A. SkupaiD· 2 shared Achyuth KalluchiiD· 1 shared Aguirre A de CubasiD· 1 shared Akshay KrishnaiD· 1 shared Alexandria P. EikeniD· 1 shared Amarnath NatarajaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Audrey L. SmithORCID

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2 papers

Recent·Most cited

Cancer BiologyFrontiers in OncologyPeer-reviewedJul 21, 2026

Impact of high-fat Western diet on chronic lymphocytic leukemia disease progression and gut microbiome profile in Eμ-TCL1 mice

Sydney A. Skupa, Jordan B. Hernandez, Audrey L. Smith…·Dalia El‐Gamal

This study shows that a high-fat Western diet accelerates CLL progression and alters gut microbiome composition in Eμ-TCL1 mice.

DOI 10.3389/fonc.2026.1842275

mousemetagenomics

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Cancer BiologybioRxivJan 31, 2024

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

Alexandria P. Eiken, Audrey L. Smith, Sydney A. Skupa…·Dalia El-Gamal

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

DOI 10.1158/2767-9764.crc-24-0071

humanmouse

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