Developmental BiologyCellPeer-reviewed
An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells
Sarah Bowling, Duluxan Sritharan, Fernando G. Osorio…·Fernando D. Camargo
The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.