Fernando D. Camargo

Choline Kinase Alpha Inhibition is a Mutation Agnostic Therapeutic Vulnerability in Clonal Hematopoiesis

This study identifies CHKA/PAF metabolic dependency in clonal hematopoiesis across multiple mutations and shows its suppression reduces clonal expansion.

Early-life stromal niches orchestrate B lymphopoiesis at the brain's borders

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells

Niche signals regulate continuous transcriptional states in hematopoietic stem cells

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells

The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.

Lineage tracing on transcriptional landscapes links state to fate during differentiation

This study uses DNA barcodes to trace single-cell transcriptomes during differentiation, identifying fate biases and developmental hierarchies in hematopoiesis.

Single-cell time-series mapping of cell fate trajectories reveals an expanded developmental potential for human PSC-derived distal lung progenitors

The paper maps cell fate trajectories of human PSC-derived distal lung progenitors using scRNA-seq and identifies developmental plasticity regulated by Wnt signaling.

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.