Sachin H Patel

A glucocorticoid-responsive polygenic signature in the anterior cingulate cortex moderates the association of early-life adversity and vulnerability for depression

The paper identifies a glucocorticoid-responsive gene network in the anterior cingulate cortex that moderates the link between early-life adversity and depression risk in adult females.

Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers

This study shows that Afadin is essential for sorting retinal neuron types into correct cellular layers, but not for their survival or synaptic partner selection.

Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes

The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.

Microglial function moderates the relation between depression risk factors and depression outcomes across the life course in females

The paper shows that microglial function influences how depression risk factors affect depression outcomes differently in females compared to males across the life course.

An engineered CRISPR/Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells

The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.