Sarah Bowling

This study uses CRISPR-mediated lineage tracing to show that adipose depot identity is shaped by anatomical niche rather than embryonic lineage.

This study identifies the murine dura mater as a transient niche for early-postnatal B lymphopoiesis, highlighting the role of CXCL12-expressing fibroblasts in supporting B cell development.

The paper shows that winner cells in cell competition induce L-Proline uptake in loser cells, repressing the integrated stress response and leading to their elimination.

The paper shows that p53-deficient embryonic stem cells outcompete wild-type cells during differentiation, eliminating them via apoptosis through local interactions.

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.

This study identifies DRP1-mediated mitochondrial dynamics as a regulator of apoptotic response during embryonic differentiation in mouse cells.