Sudarshan Gadadhar

This study shows endosulfan disrupts Hedgehog signaling by altering GSK3β activity, leading to ciliopathy-like effects in mice and linking to human reproductive disorders.

This study shows endosulfan, a pesticide, suppresses hedgehog signaling by activating GSK3β and repressing GLI-regulated genes, mimicking genetic ciliopathies.

The paper identifies a glutamylated vimentin proteoform using a synthetic binder and shows its dynamic regulation during epithelial-mesenchymal plasticity.

This study shows that tubulin glycylation affects ciliary microtubule stability and motor protein interactions, enhancing kinesin-2 activity and protecting microtubules from depolymerization.

The paper develops IntAct-U-ExM to visualize actin networks with super-resolution, showing improved resolution of actin structures in yeast and mammalian cells.

This study shows that glutamylation imbalance in photoreceptor cells leads to structural defects and degeneration, highlighting its role in maintaining outer segment architecture.