Zhifu Sun

This study links germline variation to tumor evolutionary dynamics in multiple myeloma, identifying TBKBP1 as a mediator of subclonal expansion and clinical outcomes.

The paper introduces ceQTL, a method to detect eQTLs that affect transcription factor binding and target gene regulation using differential co-expression analysis.

This study shows that intestinal stem cells from IBD patients retain epigenetic memory of inflammation, leading to heightened responses to future injury but also increased risk of relapse.

Immunopipe provides a flexible pipeline for integrated analysis of scRNA-seq and scTCR-seq data to enhance understanding of T-cell immunity and immunotherapy.

The paper evaluates nine FFPE DNA extraction methods for NGS, finding average WES coverage of ~20-30X and 99% genotype concordance with targeted panels.